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Triple-drug Safety Study Reaches Important Milestone

The DOLF project celebrated an important milestone on February 9th. Our Community Based Safety Study of 2-drug vs. 3-drug Therapy for Lymphatic Filariasis completed enrolling and treating 10,000 participants in each of the treatment arms. This achieves the primary objective of the study: measuring the treatment related adverse events following treatment with the 3-drug combination therapy as compared to the standard 2-drug therapy. Soon, DOLF investigators will provide the dataset to an independent review committee at the WHO. This is the first step toward a WHO decision about whether to recommend the 3-drug therapy for mass drug administration programs to eliminate lymphatic filariasis outside of Africa.

Many people across the globe have worked hard to reach this milestone. In September 2015 the study was proposed at a meeting in Seattle. Seventeen months later DOLF collaborators have dosed more than 20,000 participants across 4 countries! But, the work is not over. While enrollment is completed at study sites in Indonesia and Haiti, our collaborators in India and Papua New Guinea will continue until they have reached their enrollment targets. A related study will soon be initiated at a fifth site in Fiji. Other aspects of the study including community acceptance surveys, and efficacy follow-up studies will continue into 2018.

HaitiDistribution IndonesiaEnrollment
Study staff enrolling and distributing drugs at sites in Haiti and Indonesia. Teams like these have worked hard to enroll more than 20,000 participants in 5 months across study sites in Haiti, India, Indonesia, and Papua New Guinea.


Postdoctoral Fellowship: Translational and operational research on neglected tropical diseases

Washington University has support from the Bill & Melinda Gates Foundation for research related to elimination and control programs for lymphatic filariasis, onchocerciasis, and soil transmitted helminth infections (see www.dolf.wustl.edu). We are seeking a postdoctoral fellow to work on development of improved diagnostic tests for these infections and to participate in applied field research projects in Africa and Asia. The successful applicant will have experience in molecular parasitology and applied field research and be able to work with a diverse group of scientists from different disciplines. Although the position will be based in St. Louis, the job requires extensive international travel to developing countries. For this reason, U.S. Citizenship or permanent residency is greatly preferred to facility foreign travel and reentry into the USA. Please reply with your C.V. and a summary of your research interests and career goals to Peter Fischer (pufische@dom.wustl.edu) or Gary Weil (gweil@dom.wustl.edu).


DOLF Shows off Innovative Electronic Data Capture Tool for Clinical Trials at COR-NTD Meeting - November 10, 2016

Joshua Bogus, Project Manager for the DOLF project, supported by the Gates Foundation, presenting the CliniOps eSource solution, at the Coalition for Operational Research on Neglected Tropical Disease Conference (COR-NTD), Atlanta, Nov, 2016

Joshua Bogus, Project Manager for the DOLF project, supported by the Gates Foundation, presenting the CliniOps eSource solution, at the Coalition for Operational Research on Neglected Tropical Disease Conference (COR-NTD), Atlanta, Nov, 2016

Last November at the COR-NTD Innovation Lab in Atlanta DOLF Project Manager, Joshua Bogus, demonstrated the capabilities of a tablet-based electronic data capture system that is being used in the Community Based Safety Study of 2-drug vs. 3-drug Therapy for Lymphatic Filariasis. This study is set to collect about 30,000 patient data, across 5 countries, within a span of 12 months.

The DOLF project team implemented CliniTrial, a proprietary mobile, cloud-based data collection solution for clinical trials developed by CliniOps (http://cliniops.com). The system allows data to be collected off-line and uploaded later. This overcame a major obstacle faced by the DOLF team in attempting to collect data electronically without regular internet access at some of the remote study sites. Joshua Bogus presented CliniTrial to other neglected tropical disease researchers and explained how they might use the system in their own clinical trials.

 


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